The inhibition of PDE-five in these tissues by sildenafil would be the foundation for the enhanced platelet anti-aggregatory activity of nitric oxide observed in vitro, as well as the gentle peripheral arterial-venous dilatation in vivo.????? ??? ?? ??????????? ?????? ???? ??? ??????? ????? ?? ??? ??????? ?????? ???? ???? ??? ?? ???????, ??????????
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